A normal, average guy who lives in New York City becomes dependent on an evil, disembodied brain. The brain feeds the guy a narcotic substance in exchange for his unwilling assistance in obtaining the brains of innocent victims for sustenance. This turns into a tour of circa-1980s underground NYC clubs, backlots, and other seedy locations. One scene features the band Swimming Pool Cues playing the song "Corruption."

A medical school dropout loses his fiancée in a tragic lawnmower incident, and decides to bring her back. Unfortunately, he was only able to save her head, so he goes to the red light district in the city and lures prostitutes into a hotel room so he can get parts for his girlfriend.